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Platensimycin update

31 January 2009 - Total synthesis

Quick update on platensimycin total synthesis with two stragglers (see earlier post here). Matsuo et al. (DOI) create the tetracyclic core in a radical reaction akin the Barton-McCombie deoxygenation:

The synthesis of the precursor molecule is a thiol ene reaction with thiophenol.

Ghosh & Xi (DOI) obtain a similar looking derivative through an intramolecular Diels-Alder reaction: