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Novel envirofriendly difluoromethylation

29 February 2013 - CRD 109

difluoromethyl_ethers_Hartwig_2013.PNG What : difluoromethylation
Reagent: difluoromethyltriflate, air stable liquid
Source: DOI (Fier & Hartwig)
Rationale: current methods require ozone depleting Freon 22 (gas) Relevant to pharma (example Pantoprazole)
Substrates: Phenols, aryl boronic acids
Mechanism: proceeds via difluorocarbene. Isotope labeling evidence